Summary and Symptoms:
According to Muscular Dystrophy Association, “Duchenne Muscular Dystrophy is a genetic disorder characterized by progressive muscle degeneration and weakness” (MDA). It is one of nine types of muscular dystrophy. DMD is caused by an absence of dystrophin, a protein that helps keep muscle cells intact. Symptom onset is in early childhood, usually between ages 3 and 5. The disease primarily affects boys, but in rare cases, it can affect girls.’’ Also according to parent project Muscular Dystrophy (PPMD), Duchenne results in progressive loss of strength and is caused by a mutation in the gene that encodes for dystrophin. Because dystrophin is absent, the muscle cells are easily damaged. The progressive muscle weakness leads to serious medical problems, particularly issues relating to the heart and lungs. Young men with Duchenne typically live into their late twenties. |
Treatments:
According to WebMD, there are no treatments for Duchenne Muscular Dystrophy (DMD), but there are medical and other therapies to keep a child’s heart and lungs healthy (“DMD”). Eteplirsen is another treatment that has been approved to treat DMD. It is an injectable medication that helps treat individuals with a specific mutation in the gene that leads to DMD. You can use treatments examples like Corticosteroids and Heart medications.
According to WebMD, there are no treatments for Duchenne Muscular Dystrophy (DMD), but there are medical and other therapies to keep a child’s heart and lungs healthy (“DMD”). Eteplirsen is another treatment that has been approved to treat DMD. It is an injectable medication that helps treat individuals with a specific mutation in the gene that leads to DMD. You can use treatments examples like Corticosteroids and Heart medications.
Mode of Genetic Inheritance:
According to the National Human Genome Research Institute, “Duchenne muscular dystrophy is inherited in an X-linked recessive pattern” (NIH). Also according to MDA.org "Each son born to a woman with a dystrophin mutation on one of her two X chromosomes has a 50 percent chance of inheriting the flawed gene and having DMD. Each of her daughters has a 50 percent chance of inheriting the mutation and being a carrier.”
According to the National Human Genome Research Institute, “Duchenne muscular dystrophy is inherited in an X-linked recessive pattern” (NIH). Also according to MDA.org "Each son born to a woman with a dystrophin mutation on one of her two X chromosomes has a 50 percent chance of inheriting the flawed gene and having DMD. Each of her daughters has a 50 percent chance of inheriting the mutation and being a carrier.”
How common is the Genetic Disorder:
According to Kidshealth, 1 in 3,500 males are born with the genetic disorder (“Muscular Dystrophy”). This disorder is more common in male toddlers than female toddlers. The genetic disorder can be to girls but will not affect them. Kids who have this disorder have gotten weaker every time and they will continue to get weak so they need special treatment. This genetic disorder is can be early as 3 years old. It can be a very deadly genetic disorder.
3 Current Research Project:According to the MDA, MDA-supported researchers are actively pursuing several exciting strategies in DMD, such as gene therapy, exon skipping, stop codon read-through and gene repair. Human clinical trials are underway for some of these strategies. For an overview of DMD research strategies and the latest research news, see.
According to MDA, Scientist around the globe have conducted intense research to understand what DMD is they have found out that DMD is a rare disorder it has fewer than 200,000 US cases per year and they found out that Treatment can help but the disorder cannot be cured it can be a lifelong disorder.
According to MDA, Scientist around the globe have conducted intense research to understand what DMD is they have found out that DMD is a rare disorder it has fewer than 200,000 US cases per year and they found out that Treatment can help but the disorder cannot be cured it can be a lifelong disorder.
Work cited
“Muscular Dystrophy.” Edited by Rupal Christine Gupta, KidsHealth, The Nemours Foundation, July 2014, kidshealth.org/en/parents/muscular-dystrophy.html.
“Duchenne Muscular Dystrophy (DMD).” Muscular Dystrophy Association, 19 Mar. 2018, www.mda.org/disease/duchenne-muscular-dystrophy.
“Duchenne Muscular Dystrophy.” WebMD, WebMD, 2018, www.webmd.com/children/duchenne-muscular-dystrophy
“Muscular Dystrophy.” Edited by Rupal Christine Gupta, KidsHealth, The Nemours Foundation, July 2014, kidshealth.org/en/parents/muscular-dystrophy.html.
“Duchenne Muscular Dystrophy (DMD).” Muscular Dystrophy Association, 19 Mar. 2018, www.mda.org/disease/duchenne-muscular-dystrophy.
“Duchenne Muscular Dystrophy.” WebMD, WebMD, 2018, www.webmd.com/children/duchenne-muscular-dystrophy